In addition, due to the damage of Treg differentiation, the conditional knockout of JunB in mouse CD4+ T cell is more susceptible to colitis induced by dextran sulfate sodium (DSS), and deficiency of JunB in vitro CD4+ T cells resulted in the failure of IL-2-induced Treg cell differentiation (Katagiri et al., 2019). Here, JUNB is linked to colitis.