Recently, a scRNA-seq study conducted on peripheral immune cells of patients with systemic sclerosis (SSc) revealed a novel inflammatory gene module originating from CD16+ monocytes, which included KLF10, PLAUR, JUNB and JUND; this module displayed the greatest discrimination compared to healthy control group(Kobayashi et al., 2021). This evidence concerns the gene KLF10 and systemic sclerosis.