Notably, JunB was reported to upregulate in effector Treg cells and play an essential role in eTreg-mediated immune homeostasis, and mice with JunB knockout specifically in Treg cells were reported to develop multi-organ autoimmunity, accompanied by abnormal activation of Th cells and cytokines production, including IL-4, IL-13, IFN-γ and IL-17A (Koizumi et al., 2018; Wheaton and Ciofani, 2020). Here, JUNB is linked to Autoimmunity.