In acute promyelocytic leukemia (APL), S-phase kinase-associated protein 2 (Skp2) can inhibit autophagy by reducing the expression of lncRNA HOTAIRM1 and the inactivation of GSK3β, and then inhibits the ubiquitination and degradation of PML-RARα, thus inhibiting the transcriptional activation of JunB through the PU.1/PML-RARα transcriptional complex, and ultimately prevents cell differentiation and promotes the progress of APL. The gene discussed is SKP2; the disease is acute promyelocytic leukemia.