PTEN and posterior cortical atrophy: In addition, loss of JunB in prostate epithelium of Pten-deficient mice led to the change of surrounding stroma, as suggested by the increase of S100A8, S100A9 and SPP1, proteins related to aggressive PCa, especially in monocytes/macrophages although didn’t influence the number of infiltrating immune cells (Thomsen et al., 2015).