m6A methyltransferase METTL3 was found to initiate the m6A modification of 3’-UTR of JunB mRNA, subsequently IGF2BP1, one of m6A reader, binds to m6A-modified sites and enhances the stability of JunB mRNA, thereby upregulating the protein expression of JunB, which consequently promotes the EMT of lung cancer cell lines induced by TGF-β1 (Wanna-udom et al., 2020; Suphakhong et al., 2022). Here, METTL3 is linked to lung cancer.