However, specific knockout of JunB in CAFs, a major cell group in the TME, had no effect on distant metastasis of breast cancer cells, indicating that an altered secretome of JunB-KO CAFs is not the metastatic driver although JunB regulates the proliferation, differentiation and senescence of fibroblasts (Papaioannou et al., 2018; Maity et al., 2021; Wutschka et al., 2021). The gene discussed is JUNB; the disease is breast cancer.