MYC is known to be transiently induced in liver regeneration, but the level of induction in the CIII-deficient mice was at least an order of magnitude higher than in typical liver injury models, such as 2/3 hepatectomy and bile duct ligation (Sekine et al., 2007; Zhang et al., 2019), despite that their liver disease is relatively mild when the MYC upregulation first appears. This evidence concerns the gene MYC and liver disorder.