HK2 and malignant colon neoplasm: For instance, CUR inhibited 1,2-dimethylhydrazine-induced rat colon carcinogenesis and the growth of the in vitro cultured HT29 cell line by suppressing the peroxisome proliferator-activated receptor-γ signal transduction pathway; moreover, in human colon cancer HCT116 and HT29 cells, CUR induced the dissociation of hexokinase II (HKII) from mitochondria by downregulating the expression and activity of the HKII gene, leading to mitochondria-mediated apoptosis (Giordano and Tommonaro, 2019).