RARB and cancer: For instance, in lung cancer A549 and H460 cells, CUR significantly upregulates RARβ TSG expression at both the mRNA and protein levels (Jiang et al., 2015); CUR acts through the inhibition of DNA methyltransferases and the subsequent reactivation of RASSF1A in cancer, leading to its therapeutic effects (Dammann et al., 2017).