For instance, in lung cancer A549 and H460 cells, CUR significantly upregulates RARβ TSG expression at both the mRNA and protein levels (Jiang et al., 2015); CUR acts through the inhibition of DNA methyltransferases and the subsequent reactivation of RASSF1A in cancer, leading to its therapeutic effects (Dammann et al., 2017). This evidence concerns the gene RASSF1 and cancer.