The International Prognostic Score for Early-stage CLL (IPS-E) index is a prediction model that estimates TTFT in early-stage CLL based on the IGHV mutational status, an absolute lymphocyte count (ALC) >15 × 109/L and lymph node palpability.27 Addition of THEMIS2 as predictor variable in a Cox PH model including IGHV mutational status, ALC and Rai stage at diagnosis, as surrogate for lymph node involvement, significantly improved model goodness-of-fit (likelihood ratio test; P < 0.001) (Suppl. The gene discussed is THEMIS2; the disease is B-cell chronic lymphocytic leukemia.