TP53 and B-cell chronic lymphocytic leukemia: To analyze the impact of well-known molecular characteristics of CLL on intracellular protein expression, we investigated differential protein expression (log2[fold change] ≥0.5 or ≤−0.5, adjusted P-value <0.05) associated with immunogenetic (IGHV mutational status and/or IGLV3-21R110 light chain use), cytogenetic, and genetic features (TP53 mutations).