They are assumed to modulate multiple signalling pathways; therefore, they might be considered valuable tools to identify innovative drugs for treatment of human diseases such as neurodegenerative pathologies, neuropsychiatric disorders, cancer, and so on.1–12 Crystal structures of human S1R and bovine S2R provided structural information for both receptor subtypes.13–15 S1R possesses a trimeric organization containing three distinct protomers, in which each protomer comprises a single transmembrane domain linked to four alpha-helices and one beta-barrel region for binding pocket of ligands. The gene discussed is TMBIM4; the disease is cancer.