The box diagram of the differences in immunocyte infiltration when samples were classified into disease and control groups showed significant differences of T cells CD4 memory resting, T cells CD4 memory activated, T cells regulatory (Tregs), T cells gamma delta, natural killer (NK) cells resting, Macrophages M1, Macrophages M2, and Neutrophils in PF patients compared with those in controls (Figure 5C). This evidence concerns the gene CD4 and pemphigus foliaceus.