The Venn diagram analysis of upregulated ER stress interactomes from the two AAA models indicated that only one interactome gene from the PERK pathway was overlapped, suggesting that ATF6, PERK, and IRE1 ER stress pathways play different roles in PPE-AAA, BAPN-Ang II AAA, Ang II abdominal AAA, and Ang II thoracic AAA (Figures 5B–D). The gene discussed is ERN1; the disease is triple-A syndrome.