APOE and triple-A syndrome: As shown in Figure 7A, the results showed that 617 genes, 64 genes, and 13 genes were downregulated in the ATF6-KO dataset, the PERK-KO dataset, and the IRE1-KO dataset, respectively, out of 2015 genes upregulated in the Ang II abdominal aorta (780 genes), the Ang II thoracic aorta (499 genes), and the Ang II abdominal versus thoracic aorta (736 genes), suggesting that ATF6 and the PERK ER stress pathways play more significant roles than the IRE1 pathway in promoting Ang II-induced AAA gene upregulation in ApoE-KO mice.