The upregulated genes in the aortas of patients with abdominal aortic aneurysm, Ang II abdominal and thoracic aortas partially overlapped with the interactomes of ER stress regulators ATF6, PERK, and IRE1, HPA-ER localization protein genes, and KEGG ER stress signaling genes. This evidence concerns the gene EIF2AK3 and abdominal aortic aneurysm.