Our findings are well correlated with previous reports in patients with AAA (26), and AAA mouse models, including VSMC-specific IRE1 downstream transcription factor X-box binding protein 1 (XBP1) (58)-KO mice (27), myeloid-specific IRE1-KO mice (28), VSMC-specific gasdermin D (GSDMD)-KO mice (59), and elastase-induced AAA treated with a PERK inhibitor (29) (Figure 4I). The gene discussed is EIF2AK3; the disease is triple-A syndrome.