ATF6 and PERK ER stress pathways played more significant roles than the IRE1 pathway in promoting Ang II-induced AAA gene upregulation in ApoE-KO as well as trained immunity gene upregulation; Nrf2 inhibited, but NOX2 and SET7 promoted Ang II-induced AAA in ApoE-KO transcriptome upregulation and trained immunity gene upregulation. Here, EIF2AK3 is linked to triple-A syndrome.