More importantly, the IPA showed that nine out of the top 20 pathways were identified specifically in the Ang II abdominal aorta, including RAC signaling, inflammasome signaling, differential cytokine production by IL-17A and IL-17F, HMGB1 signaling, IL-17 signaling, osteoarthritis pathway, role of hypercytokinemia and hyperchemokinemia, and role of chondrocytes and role of osteoblasts in rheumatoid arthritis signaling. Here, HMGB1 is linked to osteoarthritis.