Among them, caspase-4, gasdermin E (GSDME), and IL1β were significantly upregulated in the abdominal aorta but not in the thoracic aorta in Ang II-induced AAA, which indicates the non-canonical inflammasome-pyroptosis pathway may contribute to cell death in the abdominal aorta. The gene discussed is GSDME; the disease is triple-A syndrome.