The IPA also identified nine out of the top 20 pathways in the Ang II thoracic aorta, including systemic lupus in B cell signaling, role of pattern-recognition receptors, Fcγ receptor-mediated phagocytosis, Th1 pathway, GP6 signaling, CREB signaling, macrophage classical activation signaling, wound healing signaling, and multiple sclerosis signaling (Figure 2E). This evidence concerns the gene CREB1 and multiple sclerosis.