In contrast, the matrix metalloproteinase family gene including mmp13 and mmp14 were only upregulated in abdominal aorta.” Third, we demonstrated that the upregulated genes in the aortas of patients with abdominal aortic aneurysm, Ang II abdominal aorta, and thoracic aorta are partially overlapped with the interactomes of ER stress regulators ATF6, PERK, and IRE1, HPA-ER localization protein genes, and KEGG ER stress signaling genes. This evidence concerns the gene MMP13 and abdominal aortic aneurysm.