Recently, Yi and colleagues reported that CD8+ T cells expressing a myelin oligodendrocyte glycoprotein (MOG) peptide–MHCII CAR construct can efficiently deplete higher-affinity peptide-specific CD4+ T cells in vivo and prevent initiation of experimental autoimmune encephalomyelitis (EAE) (22). The gene discussed is MOG; the disease is experimental autoimmune encephalomyelitis.