We visually matched them with HPV-integration hotspots and conventional fragile sites (from (35, 37); violet starlets in Figure 3) and found that overlapping regions included super-enhancer-like elements and cancer driver genes such as ERBB4, CASP8, BRCA1, RARA, FGFR3, MET, JAK3, PGR, MYH, PRKCA, POLA1, IDH1, MAP2K1, PPP2R1A, CDK12, SMARCA4, PIK3R2. The gene discussed is POLA1; the disease is cancer.