We visually matched them with HPV-integration hotspots and conventional fragile sites (from (35, 37); violet starlets in Figure 3) and found that overlapping regions included super-enhancer-like elements and cancer driver genes such as ERBB4, CASP8, BRCA1, RARA, FGFR3, MET, JAK3, PGR, MYH, PRKCA, POLA1, IDH1, MAP2K1, PPP2R1A, CDK12, SMARCA4, PIK3R2. Here, PRKCA is linked to cancer.