We visually matched them with HPV-integration hotspots and conventional fragile sites (from (35, 37); violet starlets in Figure 3) and found that overlapping regions included super-enhancer-like elements and cancer driver genes such as ERBB4, CASP8, BRCA1, RARA, FGFR3, MET, JAK3, PGR, MYH, PRKCA, POLA1, IDH1, MAP2K1, PPP2R1A, CDK12, SMARCA4, PIK3R2. This evidence concerns the gene CASP8 and cancer.