Recent studies have demonstrated that epithelial cell-derived cytokines, such as thymic stromal lymphopoietin (TSLP), interleukin (IL)-33, and IL-25 act on immune cells, including type-2 innate lymphoid cells (ILC2); induce type 2 immunity; and are deeply involved in the pathogenesis of AD (4, 5). Here, IL33 is linked to Alzheimer disease.