Besides CCL2/CCR2 axis, other chemoattractant-receptor interactions have also shown therapeutic potential in GBM, such as lysyl oxidase (LOX)/β1 integrin, OPN/αvβ5 integrin, and slit guidance ligand 2 (SLIT2)/Roundabout 1 and 2 (ROBO1/2) (71, 118, 119). Here, SPP1 is linked to glioblastoma.