To assess anti-tumor activity, we showed that CAR133-NK92 and CAR133-i502-NK92 cells exhibited enhanced CD107a expression compared to non-transduced NK92 cells when co-cultured with hCD133+ SW620 and hCD133+ HCT116 cells, while the three effector cells had similar levels of CD107a expression when co-cultured with hCD133-SW480 cells. This evidence concerns the gene LAMP1 and neoplasm.