The production of cytokines was generally comparable between CAR133-NK92 and CAR133-i502-NK92 cells for 3 days (Supplementary Figure S2A); however, compared to CAR133-NK92 cells, CAR133-i502-NK92 cells exhibited increased production of pro-inflammatory cytokines, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-6, and IL-7, 5 days after tumor stimulation (Figure 3F). This evidence concerns the gene IL6 and neoplasm.