In contrast, CBLB502 was secreted by CAR133-NK92 cells engineered with CBLB502 when the cells were co-cultured with hCD133+ SW620 cells, but not in the presence of hCD133-SW480 cells, which indicated that CAR133-i502-NK92 cells initiated CBLB502 release when exposed to CD133-positive tumor cells. Here, PROM1 is linked to neoplasm.