PPARA and retinal disorder: To deal with these questions, using ARPE‐19 cells (human RPE cell lines), we explored the role of PPAR‐α and the effect of HBO in the pathomechanism of IR‐related retinopathy, including reduced mitochondrial biogenesis, decreased cell viability, reduced PPAR‐α expression, increased oxidative stress, blood‐retinal barrier disruption, apoptosis and autophagy in vitro.