Interestingly, Toll‐like receptor signalling was detected in sepsis, specifically in the brain (prefrontal cortex and hippocampus), via the upregulation of genes such as CD14, TLR1, TLR2, TLR3, TLR7, IRAK3 and IRAK4 (Figure 2A). This evidence concerns the gene IRAK4 and Sepsis.