Indeed, loss of members of the arrest signaling pathways that promote senescence, including p16INK4a, p15INK4b, p14/p19ARF, p53, or Rb all result in increased rates of cancer (Donehower et al., 1992; Jacks et al., 1992; Krimpenfort et al., 2007; Pomerantz et al., 1998; Sharpless et al., 2001). Here, CDKN2A is linked to cancer.