SLC5A2 and Hyperglycemia: Several mechanisms have been identified for the beneficial effects of SGLT-2 inhibitors on DN including: (1) the restoration of tubuloglomerular feedback with reversal of afferent arteriole vasodilation and glomerular hyperperfusion; (2) a reduction in hyperglycemia-mediated reactive oxygen species (ROS); and (3) reduced renal tubular injury and inflammation40,41.