The patients in Tertile3 (T3) group were older and more female, higher proportion of patients suffering from atrial fibrillation (AF), acute kidney injury (AKI), acute respiratory distress syndrome (ARDS) and sepsis, lower proportion of patients with hypertension and hyperlipidemia, and fewer patients using aspirin, beta blockers, diuretics, statin, insulin, and oral hypoglycemic agents. This evidence concerns the gene INS and acute kidney injury.