MAPT and tauopathy: Given our findings of SNHG8 dysregulation in iPSC-derived neurons from MAPT mutation carriers, mouse brains with tau aggregation, and human brains from tauopathy patients, we asked whether this effect occurs via direct interaction between tau and SNHG8. CatRAPID, a bioinformatic platform that predicts interactions between protein and RNA based on structure data, was employed [30].