Furthermore, observations of elasmoid scales, which share a similar transcriptomic profile with the mammalian skeleton, including genes related to human diseases,46 highlighted higher TRAP staining and more circular scales in zebrafish lacking omd. As osteoclasts induce Omd expression in mature osteoblasts,31 OMD exerts negative feedback regulation on them. This evidence concerns the gene OMD and occult macular dystrophy.