As an example, the correlations with CDKL3 and FBXO31, two genes encoding for proteins involved in proliferation, showed similar behavior in READ and ESCA, with a negative correlation in WT P53 tumors and a positive correlation in P53 mutant tumors, whereas quite opposite correlation changes were observed in GBM, CESC, and KICH. The gene discussed is CDKL3; the disease is glioblastoma.