MAPT expression was highly variable, with brain glioblastoma multiforme (GBM), lower grade glioma (LGG), and neuroendocrine (pheochromocytoma and paraganglioma, PCPG) tumors showing the highest expression followed by breast cancer (BRCA) (Fig. 1a). Here, MAPT is linked to hereditary pheochromocytoma-paraganglioma.