NFKB1 and infection: We reported that NLRP3 is transcribed de novo in neutrophils in response to NFκB-activating mediators4; it is therefore likely that in the absence of priming by LPS, a 3 h PAO1 infection at a 10:1 multiplicity of infection does not induce sufficient NLRP3 expression in bone marrow neutrophils, leaving NLRC4 as the default inflammasome sensor responding to P. aeruginosa.