An essential functional contribution of SOS1 to LUAD is also consistent with the known landscape of genomic alterations in LUAD52, which preferentially impact components of RTK/RAS/ERK signaling, where SOS1 is a key regulator of downstream signaling not only by normal, non-mutated RAS proteins but also by oncogenically mutated, cancer-inducing RAS isoforms9,52. The gene discussed is SOS1; the disease is cancer.