Besides its impact on the TME, it was also relevant that the effect of SOS1 ablation was manifested not only by inhibiting and delaying tumor development and burden during early LUAD stages but also by causing a very significant shrinkage of already developed LUAD, reducing tumor burden, cell proliferative rates and recruitment of CAFs, TAMs and T-lymphocytes in already preexisting tumors developed in adult mice expressing native levels of SOS1. This evidence concerns the gene SOS1 and neoplasm.