To corroborate the potential dysfunction of large T cell clones in MM, we investigated the effect of ICB in a genetically engineered BIcγ1 mouse model that results from transgenic BCL2 and IKK2NF-κB expression in mature germinal center B lymphocytes by the cγ1-cre allele20 (Fig. S6). The gene discussed is BCL2; the disease is Miyoshi myopathy.