In Fig. 1E, the top 20 most significant GO and KEGG pathways were listed, which were mainly enriched in pathways in cancer, cellular response to growth factor stimulus, regulation of cell cycle process, etc. Based on the hallmark pathway analysis from the Molecular Signatures Database (mSigDB), the DE-PRGs mainly enriched in pathways including the Epithelial-mesenchymal transition (EMT), TGFβ signal, and hypoxia, which indicated that these pathways might be related to the pyroptosis pattern. Here, TGFB1 is linked to cancer.