Given that its TCGA data in lung adenocarcinoma only showed a trend of high expression in tumors, we searched the GSE18842 dataset further and collected samples of lung adenocarcinoma for validation, and we found that the high expression of ALDH3A1 in lung adenocarcinoma was also associated with a poor prognosis. This evidence concerns the gene ALDH3A1 and lung adenocarcinoma.