Specifically, we sought to examine causal mediation between PBMC key drivers associated with asthma (PRF1 and NKG7 in the NK cell module; CAPZA2, ATP6AP2, CTSS, and RAB3D from the interleukin module) and nasal key drivers associated with asthma (G3BP1 and INADL from the nasal TCA module). Here, PRF1 is linked to asthma.