SIRT1 and coronary artery disorder: At this point, with substantiated CHD in need of CABG, the pro-inflammatory macrophages (M1mɸ) are probably dominating in EAT and in the coronary arteries, but also in PAT and SAT, in which SIRT1 is upregulated, possibly by compensatory mechanisms in other cell types i.e., endothelial cells and probably also adipocytes, in an attempt of dampening the inflammation.