PRELP and melanoma: In order to determine whether PRELP expression is inversely associated with an immune escape phenotype, the HLA class I expression was analyzed in PRELPhigh vs. PRELPlow melanoma lesions by in silico analysis using three different human melanoma data sets: (i) mixed melanoma metastasis (83 samples; GEO ID: GSE8401) and (ii) tumor skin cutaneous melanoma (480 samples; TCGA) (Additional file 1: Table S3).