The current research was undertaken to evaluate the correlation between the CD34 + HPSCs in the liver & peripheral blood, SDF-1α in the liver and bone marrow and its concentration gradient, and CXCR4 receptor expression with the process of liver fibrosis progression and reversion in the CCl4 rat model using biochemical, histological, immunohistochemical, and molecular biological techniques. The gene discussed is CXCL12; the disease is Hepatic fibrosis.