Roekevisch et al. studied the effects of MTX and azathioprine in adult AD patients and observed significant reduction in TARC, CTACK (Cutaneous T-Cell-Attracting Chemokine or Chemokine [C-C motif] ligand 27 – CCL27), IL-13, and VEGF (Vascular Endothelial Growth Factor).22 This evidence concerns the gene VEGFA and Alzheimer disease.