ACE2 and diabetes mellitus: As ACE2 is involved in regulating pancreatic beta-cell function, a link between SARS-CoV-2 infection and beta-cell dysfunction and diabetes development has been suggested.15 Interestingly, the prevalence of elevated HbA1c below the diabetes diagnostic threshold (pre-diabetes) was markedly higher in our COVID-19 cohort than in our previous pre-COVID-19 cohort (40% vs 9%).