TP53 and obesity due to melanocortin 4 receptor deficiency: It is further interesting that PGF2αEA presented no proliferative effect in the other tested cell lines herein, and it also exhibited a targeted effect as it did not equally affect all the analyzed genes controlling the cell cycle while exerting no impact on the tumor-suppressor gene Trp53. These observations point to a selective and specific, rather than uncontrolled and ubiquitous, action of PGF2αEA and further strengthen its position as a promising preadipocyte regulating mediator, thus stimulating more research within the field of obesity.