In this study, through a combined analysis of bulk-sequencing data and 4 sets of scRNAseq data, we successfully identified a series of CRPC-specific features such as increased number of PEG10+ neuroendocrine cells, enhanced expression of PPIB/GAPDH/AR gene set in tumor cells, elevated expression of TGFB1 in TMEs suppressed immune environments such as M2 macrophage polarization, T cell exhaustion, as well as increased number of regulatory B cells. Here, PPIB is linked to neoplasm.