In macrophage cells from CRPC samples, we find relatively higher expression of M2 polarization markers TGFB1/IL10, as well as lower expression of M1 polarization markers TNF/IL1B compared to cells from PCa samples (Figure 6H), suggesting an enhanced M2 polarization process in CRPC samples. This evidence concerns the gene TGFB1 and posterior cortical atrophy.