In line with this observation, 2 main transcriptomic (C1 and C2) and epigenomic (Epi-CA and Epi-CB) HB subtypes have been identified and associated with clinical behavior.5,6 In particular, the C2 subtype displays features of aggressive tumors characterized by having a stemness-like profile, high proliferation, and upregulation of MYC protein (MYC) target genes, resulting in a poor clinical outcome. This evidence concerns the gene MYC and hemoglobin measurement.