Moreover, they are closely linked to cancer initiation, progression, and metastasis.(15) The plasma fibrinogen level increases in a hypercoagulable and inflammatory state.(16) Serum albumin has been shown to be a prognostic factor in lung and other cancers.(17) Wen et al. found that fibrinogen-to-albumin ratio was an independent prognostic factor for all-cause cancer mortality.(18) Therefore, BUN, albumin, and fibrinogen were selected for the developed model. This evidence concerns the gene ALB and cancer.