Other parameters closely associated to the inflammatory response which also have been evidenced to play a prognostic role in cancers could be considered such as neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, lymphocyte/monocyte ratio, and interleukin-6.(4) The identification of novel serum biomarkers in lung cancer by proteomics and metabolomics is essential and may help to further refine predictor tools. This evidence concerns the gene IL6 and cancer.