Here, we present an NSC model of APOE genetic variations which shows altered expressions of several aging markers such as autophagy-related 7 (ATG7), fibroblast growth factor 2 (FGF2), phosphatase and tensin homolog (PTEN), and sirtuin 1 (SIRT1), all of which depend on APOE4 in the context of late-onset AD. This evidence concerns the gene SIRT1 and Alzheimer disease.