AC is characterized by alterations in the Wnt/b-catenin pathway, mainly involving the central regulatory gene CTNNB1, while papillary craniopharyngioma is mostly driven by the V600E mutation in the BRAF gene, which activates the mitogen-activated protein kinase (MAPK) signaling pathway [186–189]. The gene discussed is BRAF; the disease is Papillary Craniopharyngioma.