For example, Cheng et al.’s study based on the TCGA database showed that RAC3 was upregulated in patients with bladder tumors, and that RAC3 may promote the proliferation, migration, and invasion of bladder tumor cells through the PYCR1/JAK/STAT signaling pathway [2, 22], but it has not yet been demonstrated at the clinical level. Here, PYCR1 is linked to urinary bladder neoplasm.