TIMP2 and chronic kidney disease: Neutrophil gelatinase-associated lipocalin (NGAL), in patient with CKD and acute heart failure (AHF), has a diagnostic and prognostic value [31]; the combination of tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor binding protein 7 (IFGBP7) is a useful diagnostic and prognostic biomarker in AKI [32].