In adults, the high prior prevalence of type 2 diabetes means negative islet autoantibodies (if measured close to diagnosis) will be strongly suggestive of diabetes with a non-autoimmune aetiology (type 2 diabetes or MODY), with research suggesting that the majority of islet-autoantibody-negative adults clinically thought to have type 1 diabetes are not likely to have this condition and that many individuals within this group can successfully and safely stop insulin treatment [31, 32]. This evidence concerns the gene INS and MODY.