NPHS1 and focal segmental glomerulosclerosis: While NPHS1, NPHS2, PLCE1, and LAMB2 are mostly associated with early-onset severe NS during the fetal period or first year of life, with rapid progression to KF, other recessive genes like MYO1E (OMIM 601479) are more likely associated with childhood-onset FSGS/SRNS and a later development of KF.