INF2 encodes the inverted formin 2, involved in podocyte shape through actin cytoskeleton regulation and it is expressed in podocyte but also in heart, liver, and peripheral nerves, explaining the association with the Charcot-Marie-Tooth (CMT) neuropathy, in which FSGS is present in 75% of cases, as reported in the study from Boyer et al. [99]. Here, INF2 is linked to focal segmental glomerulosclerosis.