ACTN4 and focal segmental glomerulosclerosis: INF2 (OMIM 610982) is the most frequent autosomal dominant gene, responsible for 9–17% of adult familial FSGS, while TRPC6 (OMIM 603652) and ACTN4 (OMIM 604638) account for up to 12% and 3.5% of late-onset dominant familial FSGS, respectively [93–97].