Chen et al. confirmed that the protective mechanism of IP-ADEVs in ischemic stroke was associated with transferring circSHOC2 to neurons, and circSHOC2 promoted the expression of downstream target gene SIRT1 by inhibiting autophagy and sponging miR-7670-3p to promote neuronal survival and improve cell damage [166]. Here, SIRT1 is linked to ischemic stroke.