Under normal conditions, JNK is located in the mitochondria and cytoplasm/nucleus; however, when myocardial ischemia and/or reperfusion occurs, JNK is phosphorylated in the cytoplasm and nucleus, and activated JNK is transported to the outer mitochondrial membrane, thus triggering B-cell lymphoma 2 (Bcl2)-regulated autophagy and aggravating myocardial injury [61]. The gene discussed is MAPK8; the disease is myocardial ischemia.