TLR4 and memory: Through TLR4/NFκB and AKT/ glycogen synthase kinase 3β (GSK-3β) signal pathways, MG136-pMG36eGLP-1 could significantly reduce the memory impairment induced by LPS and motor dysfunction induced by LPS. It also decreased the abundance of pathogens Enterococcus and Proteus and increased the abundance of probiotics A. muciniphila.