In this study, we evaluate the circadian rhythm of three recently generated mice models of human KCNMA1 channelopathy variants, Kcnma1N999S/WT, Kcnma1D434G/D434G, and Kcnma1H444Q/H444Q (Park et al., 2022). This evidence concerns the gene KCNMA1 and channelopathy.