Our experimental studies in mouse models have characterized a “cocktail” of GPCR ligands – annexin A1 (ANXA1), stromal cell‐derived factor‐1 (SDF1 or CXCL12) and complement component C3 (C3a) – which improve mouse islet functional survival in an inflammatory environment in vitro,23 and improve the ability of pretreated islet grafts to maintain normoglycaemia in a mouse model of T1D.23 This evidence concerns the gene ANXA1 and type 1 diabetes mellitus.