APP and Alzheimer disease: The human ortholog of ADM-2, ADAM9, has been implicated in AD and is suggested to regulate the shedding of APP as an alpha-secretase, either indirectly by regulating ADAM10 or by functioning as an alpha-secretase itself, cleaving APP in a non-amyloidogenic manner (Asai et al., 2003; Moss et al., 2011).