USP1 and non-small cell lung carcinoma: Additionally, the USP1/UAF1 inhibitors pimozide and GW7647 exert synergetic activity with cisplatin in cisplatin-resistant NSCLC cells (H596, NCI), but not in cisplatin-sensitive NSCLC cells (H460, NCI) [190], which may be a viable means of overcoming drug resistance.