NLRP3 and cancer: For example, ROS plays an important role in NLRP3 inflammasome activation (Moossavi et al. 2018; Yang et al. 2019), IFIT2 plays a role in apoptosis and cancer progression (Pidugu et al. 2019), and IFNs contribute to antitumor activity (Aricò et al. 2019; Lu et al. 2019).