The results exhibited varying degrees of upregulation in the expression of DERL2, EDEM1, SEL1L and HRD1 in Hep3B cells of the sh‐FAM134B group when compared to the sh‐NC group (p < 0.05, Figure 5A,B), indicating the effective induction of ER stress in Hep3B liver cancer cells by sh‐FAM134B. Here, DERL2 is linked to liver cancer.